Influence of Cardiopulmonary Bypass on Platelet Function

The platelet function defect of cardiopulmonary bypass.

The use of cardiopulmonary bypass (CPB) during cardiac surgery is associated with a hemostatic defect, the hallmark of which is a markedly prolonged bleeding time. However, the nature of the putative platelet function defect is controversial. In this study, blood was analyzed at 10 time points before, during, and after CPB. We used a whole-blood flow cytometric assay to study platelet surface g...

Platelet function defects related to cardiopulmonary bypass.

Rapid recovery of platelet function after cardiopulmonary bypass.

The complex mechanism of altered platelet function during cardiopulmonary bypass (CPB) is a subject under investigation because it might result in understanding of blood-biomaterial interaction and, subsequently, optimal intervention. However, the common biochemical and functional parameters of platelets do not clarify the mechanism.’ Recently, new apparatuses were constructed to mimic the hemo...

CONTINUING EDUCATION Coagulation and Platelet Function During Cardiopulmonary Bypass Surgery

Bachmann and coworkers in Chicago have performed a careful study of coagulation parameters after cardiopulmonary bypass surgery .1 In 512 patients, they found a 4% incidence of postoperative bleeding. More than half of these cases were due to surgically correctable causes. About 2% of the population were considered to be bleeding because of an acquired coagulation disorder. One half of these ca...

Platelet aggregation: effects of cardiopulmonary bypass.

This study was designed to determine whether reduction in platelet aggregate microembolization during the first 30 minutes of cardiopulmonary bypass is due to thrombocytopenia or to decreased ability of platelets to aggregate. The total volume of platelet aggregates induced in blood by adenosine diphosphate (ADP) was measured with a Coulter counter. The volume of platelets in blood was calculat...